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Progression of microglial activation preceding or paralleling neurodegeneration as the disease advances has also been demonstrated using microglial activation scanning with the more accurate tracer [11C] DPA713.[230] A significant increase in microglial activation was seen in the occipital, temporal, and parietal cortex in Parkinson patients

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In addition to its pro-differentiating actions, nicotinamide promotes neuronal survival, especially in oxidative stress environments, through various pathways, such as maintenance of protein kinase B (akt)-dependent phosphorylation of forkhead transcription factor (FOXO3a)

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